2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid CAS 503309-11-3: A Buyer’s Guide to Specifications, COA, and Bulk Supply

2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid, CAS 503309-11-3, is an aryl boronic acid used primarily as a building block in palladium-catalyzed cross-coupling and pharmaceutical intermediate synthesis. For procurement, I recommend evaluating more than the product name alone: confirm identity, assay, moisture, appearance, packaging, analytical documentation, MOQ, lead time, and shipping requirements. Maison Chemical supplies this specialty intermediate for laboratory, process-development, and bulk purchasing programs, with specifications and documentation reviewed according to the buyer’s application.

Click here to get more.

Who This Buyer’s Guide Is For

This guide is intended for pharmaceutical companies, contract development and manufacturing organizations, research laboratories, fine chemical distributors, and procurement teams sourcing CAS 503309-11-3. It is especially useful when a project requires a defined aryl boronic acid rather than a general boronic acid reagent. Buyers can use the framework below to compare supplier quotations on technical suitability, documentation, supply continuity, and total purchasing risk.

The compound may be purchased for route scouting, medicinal chemistry, process development, or larger-scale intermediate manufacturing. Requirements can differ significantly between these stages, so I do not recommend applying one universal specification to every project. A small research order may prioritize availability and pack size, while a commercial development program may require tighter controls, batch consistency, and a documented change-notification process.

Basic Product Context

2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid contains an aryl boronic acid group together with fluoro and trifluoromethyl substituents on the aromatic ring. Its boronic acid functionality makes it relevant to carbon–carbon bond-forming chemistry, particularly Suzuki–Miyaura-type coupling strategies when paired with a suitable aryl or heteroaryl halide. The fluoro and trifluoromethyl groups can also provide useful structural features during the design of fluorinated pharmaceutical intermediates.

The commonly referenced chemical identifier is CAS 503309-11-3. A calculated molecular formula associated with this substituted phenylboronic acid structure is C₇H₅BF₄O₂, with a calculated molecular weight of approximately 207.92 g/mol; buyers should still confirm the supplier’s current specification and analytical assignment before using these values for regulated or validated work. Chemical behavior may be influenced by moisture, storage conditions, solvent system, catalyst selection, and the quality of the reaction inputs.

Specifications Buyers Should Review

Identity and Assay

The first review point is whether the material matches CAS 503309-11-3 and the intended molecular structure. I recommend requesting the product name, CAS number, molecular formula, molecular weight, assay method, and representative analytical data before placing a bulk order. A COA should identify the batch number and report the measured result against the agreed specification rather than presenting only a generic product description.

Assay may be reported by HPLC, NMR, titration, or another method selected by the supplier and application. These methods are not automatically interchangeable, so the buyer should ask how the reported value is calculated and whether related substances, residual solvents, or water are measured separately. If a project has a fixed analytical method, provide that method or acceptance range during the quotation stage.

Physical and Handling Information

Appearance is commonly recorded as a solid or powder description, but appearance alone cannot establish chemical quality. Moisture can be important for boronic acids because water content may affect weighing, assay interpretation, reaction stoichiometry, and storage behavior. A practical purchasing specification may therefore include appearance, assay, water content, residual solvents, and impurity limits where these attributes are relevant to the process.

Packaging should protect the material from contamination and excessive exposure to humidity. The final packaging configuration depends on the order size, shipping route, internal handling procedures, and whether the customer needs a research pack or a production-oriented pack. Buyers should request the recommended storage conditions and verify that the container, label, and batch documents remain traceable from receipt through use.

How to Evaluate the COA

A certificate of analysis should be reviewed as a batch-specific quality document, not as a substitute for a technical data sheet or safety data sheet. I suggest checking the product name, CAS number, batch number, manufacturing or testing date, test items, methods, results, specification limits, and authorized approval. The document should be consistent with the package label and the material shipped.

For an early-stage project, a COA containing identity and assay may be a reasonable starting point if the customer’s internal procedures permit it. For process development or regulated supply, additional information may be needed, including water, residual solvents, related substances, elemental impurities, or stability and retest information. These requirements should be agreed before production because adding tests after manufacturing can affect cost, scheduling, and release timing.

Questions to Send Before Ordering

• Can you confirm the available assay specification for CAS 503309-11-3?
• Which analytical methods are used for identity, assay, water, and impurities?
• Can you provide a representative COA for technical review?
• What pack sizes and minimum order quantities are available?
• What is the estimated lead time for a new order and a repeat order?
• How is the material packaged for domestic or international shipment?
• Can you support customer-specific specifications or additional testing?

Matching Product Options to the Application

There is not always a single “best” grade for every buyer. Research use may require a small quantity with standard documentation, whereas process chemistry may require consistent assay, impurity control, and a repeatable supply plan. If the material will be used in a late-stage intermediate route, I recommend confirming the full analytical package and change-control expectations before making a supplier transition.

For more information, please visit Maison Chemical.

Buyers should also distinguish between a standard catalog specification and a customer-specific specification. A standard product may provide a faster quotation and simpler ordering, while a customized specification can address a defined impurity profile or documentation requirement. However, customized controls may increase the minimum order quantity, testing cost, or lead time, so the commercial and technical teams should review the trade-off together.

Pricing, MOQ, and Lead-Time Considerations

Pricing for specialty aryl boronic acids can vary with order quantity, assay target, analytical scope, packaging, production route, and shipping destination. A low unit price is not necessarily the lowest total cost if it is associated with extended lead time, insufficient documentation, or a pack size that creates avoidable inventory. Requesting quotations for sample, development, and bulk quantities can provide a more useful comparison than reviewing one price point.

Lead time should be confirmed in writing because “available” may refer to ready stock, production capacity, or a material that still requires release testing. For planning purposes, I recommend asking for the expected timeline in business days, along with the point at which the clock starts, such as purchase-order confirmation or technical approval. Buyers should also clarify whether the stated timing includes analytical release, export documentation, and transport preparation.

MOQ is another important commercial variable. A supplier may support a small development pack but apply a higher MOQ for customer-specific testing or reserved production. Maison Chemical can review the required quantity, destination, documentation package, and delivery schedule to prepare a quotation that is aligned with the actual project stage.

Supplier Evaluation Checklist

Technical Capability

Assess whether the supplier can consistently identify and control the requested material rather than simply list it in a catalog. Review the sample COA, analytical methods, packaging details, and response to technical questions. A supplier that clearly explains what is standard and what is negotiable is easier to evaluate than one that provides only a product name and price.

Supply and Documentation Support

For international B2B purchasing, documentation can be as important as the chemical itself. Confirm availability of the COA, SDS, commercial invoice, packing information, and any other documents required by your import and quality systems. Also ask how the supplier handles repeat orders, specification changes, batch traceability, and pre-shipment document review.

Communication and Risk Control

Good sourcing practice includes identifying risks before the purchase order is issued. Discuss storage, transport, hazardous-goods classification where applicable, customs information, and the process for handling an out-of-specification concern. These points do not guarantee a particular project outcome, but they help reduce avoidable delays and misunderstandings.

Why Work with Maison Chemical?

At Maison Chemical, we support buyers of 2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid CAS 503309-11-3 with a practical B2B supply approach. We can review the requested quantity, specification, intended use, packaging preference, destination, and documentation needs before issuing a commercial proposal. Our goal is to make the technical and purchasing requirements clear at the beginning of the transaction.

We understand that pharmaceutical intermediate procurement often involves several stages, from milligram-scale research to larger process quantities. For that reason, we encourage buyers to share their target timeline and quality requirements rather than requesting a price without context. Subject to product availability and technical review, we can discuss standard or project-specific supply arrangements, COA requirements, pack sizes, and repeat-order planning.

Key Takeaways

• CAS 503309-11-3 identifies 2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid, an aryl boronic acid building block used in synthetic chemistry.
• A calculated molecular weight of approximately 207.92 g/mol may be used as a reference, but the supplier’s current documentation should control purchasing decisions.
• Review identity, assay, water, residual solvents, related substances, packaging, batch traceability, and analytical methods before approving a supplier.
• Compare MOQ, lead time in business days, documentation scope, and total delivery risk—not only unit price.
• For development or bulk supply, align the specification and COA requirements before production or shipment.

Conclusion: The Practical Next Step for Buyers

The right way to source 2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid CAS 503309-11-3 is to match the material specification and documentation package to the intended stage of your project. Start by confirming the identity, required assay, analytical methods, quantity, packaging, destination, MOQ, and target delivery date. Then compare supplier quotations on technical evidence and supply reliability as well as price.

If you are evaluating Maison Chemical as a manufacturer, supplier, or export partner, send us your target quantity, required specification, COA expectations, and delivery location. We can review the request and advise on an appropriate supply option for research, process development, or bulk pharmaceutical intermediate procurement. This early technical discussion helps both sides establish clear expectations before an order is placed.

If you are looking for more details, kindly visit 2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid CAS 503309-11-3.